Isolation of Pandangolide 1 from Cladosporium oxysporum, An Endophyte of the Terrestrial Plant Alyxia reinwardtii

Pandangolide 1 was isolated from the ethyl acetate extract of Cladosporium oxysporum cultures.The fungus was originally obtained from Alyxia reinwardtii.The structure of pandangolide 1 was ULTRA-SLEEK SHAMPOO elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopy and accurate mass spectrometric data.This is the Gastro Intestinal T

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Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism

Abstract Background B-type lamins Rx - Antibiotics are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture.However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joint depletion severely impacts cell viability.To overcome this, we engineered mammali

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Evaluation of the Antimicrobial Peptide, RP557, for the Broad-Spectrum Treatment of Wound Pathogens and Biofilm

The relentless growth of multidrug resistance and generation of recalcitrant biofilm are major obstacles in treating wounds, particularly in austere military environments where broad-spectrum pathogen coverage is needed.Designed antimicrobial peptides (dAMPs) are constructed analogs of naturally occurring AMPs that provide the CHASTETREE first line

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